| Autor: |
U, Lönn, S, Lönn, S, Friberg, B, Nilsson, C, Silfverswärd, B, Stenkvist |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(10) |
| ISSN: |
1078-0432 |
| Popis: |
Amplification of c-erb-B2 is examined in patients with transitional cell bladder carcinoma. In a pilot study we found that the amplification correlated with high tumor grade. Tumor grade is a known prognostic factor. Therefore, we next examined the prognostic value of c-erb-B2 amplification in patients with16 years of clinical follow-up. The gene copy number was determined, using semiquantitative PCR, in archival formalin-fixed tissues. Twenty-three percent (37/163 patients) showed the amplification. The amplification correlated with grade and stage. Moreover, we found that tumor grade (P0.001) and c-erb-B2 amplification (P0.001) showed prognostic information for survival. Patients with grade 3 tumors and concomitant c-erb-B2 amplification showed the worst prognosis. Multivariate analysis indicates that grade and c-erb-B2 amplification are independent prognostic factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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