Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47
| Autor: | P, Chedid, T, Boussetta, P M-C, Dang, S A, Belambri, V, Marzaioli, M, Fasseau, F, Walker, A, Couvineau, J, El-Benna, J-C, Marie |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Inflammation
Male Membrane Glycoproteins Neutrophils Anti-Inflammatory Agents NADPH Oxidases Carrageenan Monocytes Rats N-Formylmethionine Leucyl-Phenylalanine Rats Sprague-Dawley NADPH Oxidase 2 Animals Edema Humans Phosphorylation Extracellular Signal-Regulated MAP Kinases Reactive Oxygen Species Cells Cultured Signal Transduction Vasoactive Intestinal Peptide |
| Zdroj: | Mucosal immunology. 10(2) |
| ISSN: | 1935-3456 |
| Popis: | Reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase (NOX2) are required for microbial clearance; however, when produced in excess they exacerbate inflammatory response and injure surrounding tissues. NOX2 is a multicomponent enzyme composed of membrane-associated cytochrome b588 and cytosolic components p47 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink