| Popis: |
A total of 60 patients with hypertrophic cardiomyopathy (HCMP) and 26 normal subjects were examined. HCMP patients showed increase in maximum ejection rate (ERmax) and shortening of time to reach it, which fact reflects augmentation of myocardial contractility in these patients. Significant alterations were also detectable in left ventricular diastolic function, manifested by a drop in maximum filling rate (FRmax), prolongation of time to reach it, diminution of filling fraction during phase of rapid filling, tendency toward increase of the filling fraction during diastasis phase and atrial systoles, reduction in indices of left ventricular volume compliance. The above alterations had a clear-cut association with the myocardial mass index. Comparative evaluation of left ventricular systolic and diastolic functions in HCMP patients indicated early and marked alterations in diastolic function of the left ventricle, preceding the development of systolic dysfunction, which fact is to be taken into account in choosing suitable medical treatment for HCMP patients. |
