| Autor: |
I Iu, Stiuf, T V, Bykova, A Iu, Zaritskiĭ, O I, Frolova, O V, Marinets, B V, Afanas'ev |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Terapevticheskii arkhiv. 70(7) |
| ISSN: |
0040-3660 |
| Popis: |
To elucidate prognostic value of MDR-1 gene expression in patients with chronic myeloid leukemia (CML).The MDR-1 gene expression was studied by in situ hybridization in hemopoietic cells of 63 Ph-positive CML patients in different phases of the disease. The survival of the patients and duration of the chronic phase (CP) were evaluated using the Caplan-Meyer method.MDR-1-positive patients had a shorter survival (p0.01) and CP (p0.05) than negative ones. MDR-1 gene overexpression has no impact either on the survival or duration of AP and BP (p0.05). Moreover, the MDR-1 gene overexpression is not dependent either on the previous treatment or other prognostic markers.Overexpression of MDR-1 gene is an independent prognostic factor and an additional parameter to Sokal's scores. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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