Atrial fibrillation: a new explanation of the old phenomenon

Autor:	Yu R, Sheikh-Zade, P A, Galenko-Yaroshevskii, I L, Cherednik
Rok vydání:	2002
Předmět:	Ions Myocardium Atrial Fibrillation Cell Membrane Cats Animals Arrhythmias Cardiac Vagus Nerve Procainamide
Zdroj:	Bulletin of experimental biology and medicine. 134(1)
ISSN:	0007-4888
Popis:	We propose a new mechanism of atrial fibrillation basing on the results of 30 series of acute experiments on anesthetized cats. In brief, combination of two or more arrhythmogenic factors shortens the interval between the inward and outward ionic currents in cardiomyocytes to a critical value. Under these conditions repolarization of cardiomyocyte membrane reaches the excitation threshold before complete inactivation of the depolarizing currents. This inevitably results in autoexcitation of myocytes (or extrasystole), that in turn promotes repolarization. Once occurred, autoexcitation turns into self-triggering activity resembling tachyarrhythmia paroxysm.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7782ad205f5feac99f381b2e6167e052 https://pubmed.ncbi.nlm.nih.gov/12459853 Zobrazit plný text záznamu Full text from SpringerLink