| Autor: |
M A, Hermsen, Y, Xie, M A, Rooimans, G A, Meijer, J P, Baak, J T, Plukker, F, Arwert, H, Joenje |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Familial cancer. 1(1) |
| ISSN: |
1389-9600 |
| Popis: |
Fanconi anemia (FA) is an autosomal recessive syndrome with a marked predisposition to malignancies, in particular acute myeloid leukemia and squamous cell carcinoma of the oral cavity. We examined oral squamous cell carcinoma tissue from two FA patients (FA-A and FA-C) by comparative genomic hybridization. Both tumors, which were negative for human papilloma as well as Epstein-Barr viral sequences, showed multiple alterations with a high proportion of whole-arm chromosomal gains and losses. This combination of features as well as the sites involved in chromosomal breakage are very similar to what is typically observed in non-FA oral tumors. These results suggest that the process leading to early occurrence of oral cancer in FA patients follows a similar pathway as in non-FA cancer patients, which would support a caretaker function for FA genes in the protection against oral carcinogenesis. Since FA patients are uniquely hypersensitive to DNA cross-linking agents, while oral cancer in the general population is thought to be environmentally induced, these results also suggest that environmental DNA cross-linkers may be causally involved in oral carcinogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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