Beneficial effect of polaprezinc on cardiac function post-myocardial infarction
Autor: | Yoshikawa, Fumitsugu, Nakajima, Tetsu, Hanada, Masaharu, Hirata, Kazuo, Masuyama, Tohru, Aikawa, Ryuichi |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Carnosine Anti-Inflammatory Agents Myocardial Infarction acute myocardial infarction Cardiovascular Agents Clinical Trial/Experimental Study Middle Aged Electrocardiography Zinc polaprezinc Percutaneous Coronary Intervention Treatment Outcome inflammation Zinc Compounds Organometallic Compounds Humans Female cardiac function Biomarkers Research Article Aged |
Zdroj: | Medicine |
ISSN: | 1536-5964 0025-7974 |
Popis: | Background: Polaprezinc is clinically used for the treatment of gastric ulcers. It induces the mobilization of mesenchymal stem cells and the mRNA expression of insulin-like growth factor-1 in vascular endothelial cells in order to protect injured gastric tissue or skin. Methods: The current study population included 50 patients with primary acute myocardial infarction (AMI). After percutaneous coronary intervention, the subjects were randomly divided into 2 groups, namely, the nonpolaprezinc and polaprezinc groups. Peripheral blood and urinary samples were collected in a specific time to analyze zinc concentration, cardiac enzymes, and the levels of the inflammation marker interleukin-6. To evaluate the cardiac function, echocardiography was performed upon admission to the hospital and at 9 months post-AMI. Results: The urine and blood zinc levels of the polaprezinc group were higher compared with those of the non-polaprezinc group at 8 days after percutaneous coronary intervention. The mean interleukin-6/maximal creatine phosphokinase level was significantly reduced in the polaprezinc group (0.024 [0.003–0.066] vs. 0.076 [0.015–0.212], respectively; P = .045). In addition, echocardiography revealed that the ejection fraction of the nonpolaprezinc group was not significantly increased between day 3 and 9 months post-AMI (53 [49–60.8] vs. 59.5 [52–69.3], respectively; P = .015). However, a significant increase was detected in the ejection fraction of the polaprezinc group at the 2 time points (54 [51–57] vs. 62 [55–71], respectively; P |
Databáze: | OpenAIRE |
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