CD177

Autor: Ruizhong, Zhang, Liang, Su, Ming, Fu, Zhe, Wang, Ledong, Tan, Hongjiao, Chen, Zefeng, Lin, Yanlu, Tong, Sige, Ma, Rongchen, Ye, Ziyang, Zhao, Ziqing, Wang, Weiyi, Chen, Jiakang, Yu, Wei, Zhong, Jixiao, Zeng, Fei, Liu, Chenwei, Chai, Xisi, Guan, Tao, Liu, Jiankun, Liang, Yun, Zhu, Xiaoqiong, Gu, Yan, Zhang, Vincent C H, Lui, Paul K H, Tam, Jonathan R, Lamb, Zhe, Wen, Yan, Chen, Huimin, Xia
Rok vydání: 2021
Předmět:
Zdroj: Journal of hepatology. 77(5)
ISSN: 1600-0641
2000-0405
Popis: We have previously reported on the potential pathogenic role of neutrophils in biliary atresia (BA). Herein, we aimed to delineate the role of CD177+ neutrophils in the pathogenesis of BA.Immune cells from the livers of mice with rhesus rotavirus-induced BA were analysed. Single-cell RNA-sequencing was performed to specifically analyse Gr-1Increased levels of Gr-1Our data indicate that CD177The pilot study of N-acetylcysteine treatment in patients with BA was registered on the Chinese Clinical Trial Registry (ChiCTR2000040505).Neutrophils (a type of innate immune cell, i.e. an immune cell that doesn't target a specific antigen) are thought to play a role in the development of biliary atresia (a rare but potentially lethal condition of the bile ducts that occurs in infants). Herein, we found that neutrophils expressing a particular protein (CD177) played an important role in bile duct damage by releasing a special structure (NET) that can trap and kill pathogens but that can also cause severe tissue damage. A pilot study in patients with biliary atresia showed that inhibiting NETs could have a beneficial effect.
Databáze: OpenAIRE
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