| Autor: |
Jie, Guo, Ying-Qian, Zhao, Hua, Li, Gai-Yue, Zhang, Yuan-Rong, Lu, Pan-Pan, Guo, Qiang, Wang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Zhen ci yan jiu = Acupuncture research. 47(12) |
| ISSN: |
1000-0607 |
| Popis: |
To observe the effect of electroacupuncture (EA) of "Xiusanzhen" ［bilateral "Yingxiang"(LI20)+"Yintang"(GV24Male C57BL/6 mice were randomly divided into control, sham operation, model and EA groups, with 10 mice in each group. The PDD model was established by injecting 6-OHDA into the medial forebrain tract. EA (2 Hz, 1 mA) was applied to unilateral LI20 and GV29 for 20 min once daily for consecutive 14 days. Morris water maze and new object recognition test were used to evaluate the learning and memory ability. Western blot was used to detect the expression of SYN and PSD-95 proteins in hippocampus. Immunofluorescence was used to label Iba-1Compared with the control group, there was no statistical significance in all the observed indexes in the sham operation group. Compared with the sham operation group, the average escape latency (AEL) prolonged significantly ("Xiusanzhen" can alleviate the learning and memory impairment of PDD model mice, and improve the synaptic plasticity of hippocampal CA1 area. The mechanism may be related to the reduction of C1q and C3 deposition in hippocampal CA1 region and the reduction of microglia phagocytosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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