| Autor: |
Christian, Kratzik, Irene, Womastek, Christian, Bieglmayer, Georg, Schatzl, Jakob, Lackner, Christa, Freibauer, Gerhard, Lunglmayr |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Anticancer research. 31(10) |
| ISSN: |
1791-7530 |
| Popis: |
Data on testosterone levels of patients with prostate cancer of different grade and stage are inconsistent. We retrospectively investigated serum total testosterone of a radical prostatectomy cohort to further shed light on this problem.The preoperative level of serum total testosterone of 217 patients (mean age: 65±5.8 years) undergoing radical prostatectomy between 1989 and 2002 was analyzed for possible associations with Gleason score (≤6 vs.7 vs. 8-10) and tumor stage (pT2 vs. pT3 vs. N+) with adjustment for age, diabetes and obesity. Patients exhibiting prostate-specific antigen (PSA) levels of10 ng/ml and biopsy Gleason scores of ≥7 were submitted to standard lymphadenectomy.The multivariate model revealed a significant effect of body mass index (BMI) (p=0.0003) and diabetes (p=0.002) on testosterone levels. Significantly lower testosterone levels were recorded in patients with nodal metastases (p0.0001) compared to patients with non metastatic disease. No significant associations between testosterone, Gleason score and stage were found in patients with non- metastatic disease.Testosterone levels prior to radical prostatectomy were lower in patients with nodal involvement. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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