| Autor: |
J G, Brockmann, H, St Nottberg, B, Glodny, B, Sprakel, N, Senninger |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Anticancer research. 20(6D) |
| ISSN: |
0250-7005 |
| Popis: |
This study was conducted to determine the use of CYFRA 21-1 for patients suffering from esophageal carcinoma.50 patients with malignant, 50 patients with benign esophageal lesions, 50 healthy persons and 50 patients with benign lung disease were tested for CYFRA 21-1, CEA, CA 72-4 and SCC-antigen serum concentrations. The patients with esophageal carcinoma underwent follow-up analysis for one year.CYFRA 21-1 (cut-off: 1.40 ng/ml) showed a sensitivity for esophageal carcinoma of 46% at a specificity of 89.3%. There was a tendency for higher serum CYFRA 21-1 concentrations in advanced T-stages. Correlations of CYFRA 21-1 with N or M stages could not be observed. The postoperative course, in terms of survival and tumor free survival showed significant correlation to pre-operative CYFRA 21-1 concentrations. Adjuvant therapy could be monitored by CYFRA 21-1 as well. Clinical tumor recurrence was preceded by CYFRA 21-1 elevation by 3.4 months.We recommend the use of CYFRA 21-1 in cases of esophageal carcinoma, especially in cases of squamous cell carcinoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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