Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
| Autor: | Golabgir Khademi, Khadijeh, Foroughmand, Ali Mohammad, Galehdari, Hamid, Yazdankhah, Saied, Pourmahdi Borujeni, Mahdi, Shahbazi, Zahra, Dinarvand, Parvaneh |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Short Communication Single nucleotide polymorphisms Coronary Artery Disease Iran Middle Aged Polymorphism Single Nucleotide Genetic Loci Risk Factors Humans Female Genetic Predisposition to Disease RNA Long Noncoding cardiovascular diseases Genetic association study Aged Genome-Wide Association Study |
| Zdroj: | Iranian Biomedical Journal |
| ISSN: | 2008-823X 1028-852X |
| Popis: | Background: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. Methods: Blood samples were collected from 200 CAD patients and 110 healthy individuals with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length polymorphism. Results: Chi-square test showed no association between rs1333040 SNP and CAD (X2: 4.66, df: 2, P=0.09). Also, there was no association between rs1004638 SNP and CAD (X2: 0.27, df: 2, P=0.88). Conclusion: No association was observed between rs1333040 and rs1004638 SNPs in the 9P21 region and CAD in Southwest of Iran. |
| Databáze: | OpenAIRE |
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