Childhood to adulthood: Accounting for age dependence in healthy-reference distributions in

Autor: Joseph W, Plummer, Matthew M, Willmering, Zackary I, Cleveland, Christopher, Towe, Jason C, Woods, Laura L, Walkup
Rok vydání: 2022
Zdroj: Magnetic resonance in medicineREFERENCES. 89(3)
ISSN: 1522-2594
Popis: Xenon-129 (We model healthy reference values forVentilation, membrane-uptake, red blood cell transfer, and red blood cell:membrane gas-exchange metrics were collected on 30 healthy subjects over an age range of 5 to 68 years. A GAMLSS model was fit against age and compared against widely used linear and generalized-linear binningAll 4 gas-exchange metrics had significant skewness, and membrane-uptake had significant kurtosis compared to a normal distribution. Age has significant impact on distribution parameters. GAMLSS-binning produced narrower bins compared to the linear and generalized-linear binning schemes and distributed signal data closer to a normal distribution.The proposed "proof-of-concept" GAMLSS-binning approach can improve diagnostic accuracy of
Databáze: OpenAIRE