| Autor: |
Ryo, Kajihara, Kei, Amari, Nariaki, Arai, Sachiho, Nagashio, Moyuru, Hayashi, Tomomi, Watanabe-Asaka, Maki, Kaidoh, Yumiko, Yokoyama, Daisuke, Maejima, Yoshiko, Kawai, Toshio, Ohhashi |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Pflugers Archiv : European journal of physiology. 473(6) |
| ISSN: |
1432-2013 |
| Popis: |
The present study aims to investigate the roles of water intake in serotonin production and release in rat jejunum. We evaluated the changes in concentrations of serotonin in the portal vein and mesenteric lymph vessel induced by the intragastric administration of distilled water. The density of granules in enterochromaffin cells and the immunoreactivity of serotonin in the jejunal villi were investigated before and after water intake. The effects of intravenous administration of serotonin and/or ketanserin on mesenteric lymph flow and concentrations of albumin and IL-22 in the lymph were also addressed. Water intake increased serotonin concentration in the portal vein, but not in the mesenteric lymph vessel. The flux of serotonin through the portal vein was significantly larger than that through the mesenteric lymph vessel. Water intake decreased the density of granules in the enterochromaffin cells and increased the immunoreactivity of serotonin in the jejunal villi. The intravenous administration of serotonin increased significantly mesenteric lymph flow and the concentrations of albumin and IL-22; both were significantly reduced by the intravenous pretreatment with ketanserin. We showed that serotonin released from enterochromaffin cells by water intake was mainly transported through the portal vein. Additionally, serotonin in blood was found to increase mesenteric lymph formation with permeant albumin in the jejunal villi via the activation of 5-HT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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