| Autor: |
C, Capparelli, P J, Kostenuik, S, Morony, C, Starnes, B, Weimann, G, Van, S, Scully, M, Qi, D L, Lacey, C R, Dunstan |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Cancer research. 60(4) |
| ISSN: |
0008-5472 |
| Popis: |
Osteoprotegerin (OPG), a novel, secreted tumor necrosis factor receptor family member that inhibits osteoclast formation and activity was examined for its activity in a syngeneic tumor model of humoral hypercalcemia of malignancy. Normal mice bearing Colon-26 tumors develop increases in both parathyroid hormone-related protein (PTHrP) expression and plasma PTHrP, marked hypercalcemia, and increased bone resorption. OPG, given either at the onset of hypercalcemia or after it had occurred, blocked tumor-induced increases in bone resorption and hypercalcemia and rapidly normalized blood ionized calcium. In tumor-bearing mice, OPG treatments reduced osteoclast activity from approximately 2-fold above normal into the subphysiological range but had no effects on tumor size, tumor-induced cachexia, or PTHrP levels. The potent effects of OPG in this humoral hypercalcemia of malignancy model suggest a potential therapeutic role for OPG in the prevention and treatment of this disorder. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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