| Autor: |
M, Loriga, G, Paglietti, S, Piras, F, Sparatore, V, Anania, M P, Demontis, M V, Varoni, M C, Fattaccio |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Farmaco (Societa chimica italiana : 1989). 47(3) |
| ISSN: |
0014-827X |
| Popis: |
Several compounds possessing imidazo[4,5-b]pyridine and benzimidazole structure bearing substituents in position 2 were prepared in order to evaluate an anti-ulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole. Among sixteen compounds taken as representatives of the synthetised series only one (3d) showed a good activity by i.m. administration at 50 mg/kg, while by oral administration of 100 mg/kg a certain number was active and in some cases this activity was quite superior to that of omeprazole. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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