| Autor: |
J E, Hixson, L, Almasy, S, Cole, S, Birnbaum, B D, Mitchell, M C, Mahaney, M P, Stern, J W, MacCluer, J, Blangero, A G, Comuzzie |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
The Journal of clinical endocrinology and metabolism. 84(9) |
| ISSN: |
0021-972X |
| Popis: |
We previously reported that our genome-scanning initiative had detected a highly significant linkage (log odds ratio = 4.95; P = 9 x 10(-7)) between a quantitative trait locus (QTL) on chromosome 2 and leptin levels in Mexican American families. We now have typed additional microsatellite markers in this region, increasing this log odds ratio score to 7.46 (P = 2 x 10(-9)). This region of chromosome 2 contains a strong positional candidate gene, POMC. The POMC gene codes for POMC, the prohormone from which alphaMSH, ACTH, and beta-endorphin are derived. Studies by others have shown that POMC-derived products are involved in the regulation of appetite and obesity. We have used polymorphisms in POMC to map its location within the 95% confidence interval of the peak for the linkage signal for the QTL. We also constructed POMC haplotypes using these polymorphisms and have found a significant association with normal variation in leptin levels (P = 0.001). We conclude that variation in POMC is associated with normal variation in serum leptin levels, providing further evidence that POMC may be the leptin QTL previously identified in Mexican American families. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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