Risk factors for the evaluation of potential central nervous system metastasis in Burkitt's lymphoma: a case study and literature review
| Autor: | Yue-Ting, Tang, Xiao-Yang, Jiao, Xiao-Lan, Chang, Dong-Yang, Huang |
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| Rok vydání: | 2014 |
| Předmět: |
Vascular Endothelial Growth Factor A
Neovascularization Pathologic Vascular Endothelial Growth Factor C Headache Brain Middle Aged Burkitt Lymphoma Immunophenotyping Recurrence Risk Factors Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Diplopia Humans Female Neoplasm Invasiveness Lymph Nodes Cerebrospinal Fluid Neoplasm Staging |
| Zdroj: | Hematological oncology. 34(1) |
| ISSN: | 1099-1069 |
| Popis: | Burkitt's lymphoma (BL) is a malignancy of B lymphocytes. The rapid growth rate and frequent systemic spread result in most patients presenting with advanced disease at diagnosis. Cerebrospinal fluid cytology is the gold standard (with very high accuracy) for diagnosing BL central nervous system (CNS) metastasis; however, the low sensitivity of this method limits its clinical applications. Here, we report a case of BL with CNS metastasis. The levels of vascular endothelial growth factor (VEGF)-A and VEGF-C in the serum and cerebrospinal fluid were used to evaluate the status of BL remission and recurrence. Comparisons were made between VEGF and the other risk factors used in evaluating CNS metastasis. Although not in strict accordance, VEGF levels mirrored the disease course. Therefore, VEGF may reflect the status of BL CNS metastasis. Understanding the role of VEGF in CNS metastasis may help to improve the staging and risk classification of BL as well as the investigation of targeted therapy. |
| Databáze: | OpenAIRE |
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