Evaluation of the effect of tumor necrosis factor-alpha gene polymorphism on the risk of peri-implantitis: a case-control study
| Autor: | Patricia R, Cury, Veronica V, Horewicz, Daniel S, Ferrari, Rui, Brito, Wilson R, Sendyk, Poliana M, Duarte, Jamil A, Shibli |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Dental Implants Male Chi-Square Distribution Tumor Necrosis Factor-alpha Middle Aged Polymorphism Single Nucleotide Young Adult Reference Values Case-Control Studies Humans Female Genetic Predisposition to Disease Dental Prosthesis Implant-Supported Dental Restoration Failure Periodontitis Aged |
| Zdroj: | The International journal of oralmaxillofacial implants. 24(6) |
| ISSN: | 0882-2786 |
| Popis: | Tumor necrosis factor-alpha (TNFalpha) is a proinflammatory cytokine, which promotes bone resorption and mediates the inflammatory response to infection. Because implant failures appear to cluster in subsets of individuals, this phenomenon may be related to gene polymorphisms. Therefore, the aim of this study was to investigate the relationship between a specific polymorphism in the TNFalpha gene (allele 2 of TNFalpha(-308)) and peri-implantitis.This case-control study included Caucasian nonsmoking Brazilian patients with implant-supported restorations. Oral epithelial cells were taken from patients with and without peri-implantitis to evaluate the frequencies of different alleles of the TNFalpha(-308) gene by polymerase chain reaction.Ninety patients (49 with peri-implantitis and 41 with healthy implants) were enrolled in this study. Polymorphism in allele 2 of TNFalpha(-308) was not associated with an increased risk for peri-implantitis (P = .8171), although 14.63% of the subjects in the control group carried allele 2 and 19.39% in the peri-implantitis group carried allele 2 (chi-squared = 0.708; P = .5202).Polymorphism of the TNFalpha(-308) gene was not associated with an increased risk of peri-implantitis in the population evaluated in this study. |
| Databáze: | OpenAIRE |
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