| Autor: |
M J, Mayaux, E, Dussaix, J, Isopet, C, Rekacewicz, L, Mandelbrot, N, Ciraru-Vigneron, M C, Allemon, V, Chambrin, C, Katlama, J F, Delfraissy, J, Puel |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
The Journal of infectious diseases. 175(1) |
| ISSN: |
0022-1899 |
| Popis: |
Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6 log at delivery, and 15% of women had levels below the detection limit. There was no variation during pregnancy. Women born in sub-Saharan Africa had lower RNA levels, although their CD4 cell distribution did not differ from that in other women. Among 236 evaluable children, 19% +/- 5% were infected. Transmission occurred in 12% of cases (confidence interval, 5%-22%) with1000 copies/mL versus 29% +/- 10% of those with10,000 copies/mL (P.02). Maternal virus load appears strongly related to HIV transmission to the child. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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