Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification† †Electronic supplementary information (ESI) available: Additional NMR and UV-Vis spectra, additional tables and proposed mechanism for impurities. See DOI: 10.1039/c7py00535k
| Autor: | Crisan, Daniel N., Creese, Oliver, Ball, Ranadeb, Brioso, Jose Luis, Martyn, Ben, Montenegro, Javier, Fernandez-Trillo, Francisco |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
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| Zdroj: | Polymer Chemistry |
| ISSN: | 1759-9962 1759-9954 |
| Popis: | Here we present the synthesis of poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers, and its post-polymerisation modification using a wide range of conditions. Here we present the synthesis and post-polymerisation modification of poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: poly(acryloyl hydrazide) was prepared from commercially available starting materials in a three step synthesis on a large scale, in good yields and high purity. Our synthetic approach included the synthesis of a Boc-protected acryloyl hydrazide, the preparation of polymers via RAFT polymerisation and the deprotection of the corresponding Boc-protected poly(acryloyl hydrazide). Post-polymerisation modification of poly(acryloyl hydrazide) was then demonstrated using a range of conditions for both hydrophilic and hydrophobic aldehydes. These experiments demonstrate the potential of poly(acryloyl hydrazide) as a scaffold in the synthesis of functional polymers, in particular those applications where in situ screening of the activity of the functionalised polymers may be required (e.g. biological applications). |
| Databáze: | OpenAIRE |
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