| Autor: |
Durbadal, Ojha, Clayton W, Winkler, Jacqueline M, Leung, Tyson A, Woods, Catherine Z, Chen, Vinod, Nair, Katherine, Taylor, Charles D, Yeh, Gregory J, Tawa, Charles L, Larson, Wei, Zheng, Cathryn L, Haigh, Karin E, Peterson |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Nature microbiology. 6(11) |
| ISSN: |
2058-5276 |
| Popis: |
La Crosse virus (LACV) is a mosquito-borne orthobunyavirus that causes approximately 60 to 80 hospitalized pediatric encephalitis cases in the United States yearly. The primary treatment for most viral encephalitis, including LACV, is palliative care, and specific antiviral therapeutics are needed. We screened the National Center for Advancing Translational Sciences library of 3,833 FDA-approved and bioactive small molecules for the ability to inhibit LACV-induced death in SH-SY5Y neuronal cells. The top three hits from the initial screen were validated by examining their ability to inhibit virus-induced cell death in multiple neuronal cell lines. Rottlerin consistently reduced LACV-induced death by 50% in multiple human and mouse neuronal cell lines with an effective concentration of 0.16-0.69 µg ml |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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