Immune and serologic profiles of HIV-infected and noninfected hemophilic children and adolescents. Hemophilia Growth and Development Study Group

Autor:	J, Jason, J, Murphy, L A, Sleeper, S M, Donfield, I, Warrier, S, Arkin, B, Evatt, E D, Gomperts
Rok vydání:	1994
Předmět:	Adult Vaccines Adolescent Immunoglobulins HIV Infections Hemophilia A Lymphocyte Subsets Antigen-Antibody Reactions CD4 Antigens Humans Lymphocytes Antigens Child Skin Tests
Zdroj:	American journal of hematology. 46(1)
ISSN:	0361-8609
Popis:	To assess relationships among the effects of HIV on hemophilic children and adolescents' immunologic parameters and vaccine-related serology.We analyzed data from extensive baseline immunologic evaluations of 207 HIV antibody-positive (HIV+) and 126 HIV antibody-negative (HIV-) hemophilic children and adolescents.HIV+ and HIV- participants differed significantly in T-lymphocyte subpopulation numbers, immunoglobulin levels, and seroprevalence rates for diphtheria toxoid, measles, and mumps antigens, IgG levels, IgM levels, and serologic titers to vaccine antigens showed little correlation with T-cell parameters. Proportionately more HIV+ participants were nonreactive to each and all of a panel of 7 skin test antigens (71% vs 28% anergic, RR 2.6). The odds of anergy increased 1.6 times for every decline of 200 CD4+ cells/microliters.HIV had significant, largely independent T- and B-lymphocyte effects on this pediatric cohort.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7575106f527d244ae3969474f6642a0a https://pubmed.ncbi.nlm.nih.gov/8184874 Zobrazit plný text záznamu Plný text