Comparative genomic hybridization (CGH) analysis of stage 4 neuroblastoma reveals high frequency of 11q deletion in tumors lacking MYCN amplification
| Autor: | D, Plantaz, J, Vandesompele, N, Van Roy, M, Lastowska, N, Bown, V, Combaret, M C, Favrot, O, Delattre, J, Michon, J, Bénard, O, Hartmann, J C, Nicholson, F M, Ross, C, Brinkschmidt, G, Laureys, H, Caron, K K, Matthay, B G, Feuerstein, F, Speleman |
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| Rok vydání: | 2001 |
| Předmět: |
Chromosome Aberrations
Male Time Factors Adolescent Models Genetic Genome Human Chromosomes Human Pair 11 Infant Nucleic Acid Hybridization Prognosis Disease-Free Survival Neuroblastoma Chromosomes Human Pair 1 Child Preschool Mutation Tumor Cells Cultured Humans Multicenter Studies as Topic Female Chromosomes Human Pair 3 Chromosome Deletion Neoplasm Metastasis Child In Situ Hybridization Fluorescence |
| Zdroj: | International journal of cancer. 91(5) |
| ISSN: | 0020-7136 |
| Popis: | We have studied the occurrence and association of 11q deletions with other chromosomal imbalances in Stage 4 neuroblastomas. To this purpose we have performed comparative genomic hybridization (CGH) analysis on 50 Stage 4 neuroblastomas and these data were analyzed together with those from 33 previously published cases. We observed a high incidence of 11q deletion in Stage 4 neuroblastoma without MYCN amplification (59%) whereas 11q loss was only observed in 15% of neuroblastomas with MYCN-amplification (p = 0.0002) or 11% of cases with 1p deletion detected by CGH (p = 0.0001). In addition, 11q loss showed significant positive correlation with 3p loss (p = 0.0002). Event-free survival was poor and not significantly different for patients with or without 11q deletion. Our study provides further evidence that Stage 4 neuroblastomas with 11q deletions represent a distinct genetic subgroup that typically shows no MYCN-amplification nor 1p deletion. Moreover, it shows that neuroblastomas with 11q deletion also often present 3p deletion. This genetic subgroup shows a similar poor prognosis as MYCN amplified 4 neuroblastomas. |
| Databáze: | OpenAIRE |
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