| Autor: |
S, Ezquerro, S, Becerril, C, Tuero, L, Méndez-Giménez, F, Mocha, R, Moncada, V, Valentí, J A, Cienfuegos, V, Catalán, J, Gómez-Ambrosi, K, Piper Hanley, G, Frühbeck, A, Rodríguez |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
International journal of obesity (2005). 44(2) |
| ISSN: |
1476-5497 |
| Popis: |
Bariatric surgery improves nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain elusive. We evaluated the potential role of ghrelin isoforms in the amelioration of hepatic inflammation after sleeve gastrectomy and Roux-en-Y gastric bypass (RYGB).Plasma ghrelin isoforms were measured in male Wistar rats (n = 129) subjected to surgical (sham operation, sleeve gastrectomy, or RYGB) or dietary interventions [fed ad libitum a normal (ND) or a high-fat diet (HFD) or pair-fed diet]. The effect of acylated and desacyl ghrelin on markers of inflammation, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress in primary rat hepatocytes under palmitate-induced lipotoxic conditions was assessed.Plasma desacyl ghrelin was decreased after sleeve gastrectomy and RYGB, whereas the acylated/desacyl ghrelin ratio was augmented. Both surgeries diminished obesity-associated hepatic steatosis, CD68Our data suggest that the increased relative acylated ghrelin levels after bariatric surgery might contribute to mitigate obesity-associated hepatic inflammation, mitochondrial dysfunction, and ER stress. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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