| Autor: |
Bin, Kong, Gan-Bin, Liu, Jun-Ai, Zhang, Xiao-Xia, Fu, Wen-Yu, Xiang, Yu-Chi, Gao, Yuan-Bin, Lu, Xian-Jing, Wu, Feng, Qiu, Wan-Dang, Wang, Lai-Long, Yi, Ji-Xin, Zhong, Zheng W, Chen, Jun-Fa, Xu |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
American journal of translational research. 8(2) |
| ISSN: |
1943-8141 |
| Popis: |
Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB). In the current study, we demonstrated that ATB patients exhibited increases in serum IL-35 and in mRNA expression of both subunits of IL-35 (p35 and EBI3) in white blood cells and peripheral blood mononuclear cells. Consistently, anti-TB drug treatment led to reduction in serum IL-35 level and p35 or EBI3 expression. TB infection was associated with expression of p35 or EBI3 protein in CD4(+) but not CD8(+) T cells. Most p35(+)CD4(+) T cells and EBI3(+)CD4(+) T cells expressed Treg-associated marker CD25. Our findings may be important in understanding immune pathogenesis of TB. IL-35 in the blood may potentially serve as a biomarker for immune status and prognosis in TB. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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