N-(2-pyridinyl)-2-[2(3H)-benzazolone-3-yl]acetamides: synthesis, antinociceptive and anti-inflammatory activity

Autor:	D S, Doğruer, S, Unlü, E, Yeşilada, M, Fethi Sahin
Rok vydání:	1998
Předmět:	Analgesics Mice Molecular Structure Pyridines Acetamides Anti-Inflammatory Agents Non-Steroidal Animals
Zdroj:	Farmaco (Societa chimica italiana : 1989). 52(12)
ISSN:	0014-827X
Popis:	Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have been elucidated by elemental analysis, IR and 1H NMR spectral data and their antinociceptive and anti-inflammatory activities were tested in mice. Compound VII o has shown the highest antinociceptive activity, and VII g, j, k, r exhibited relatively high antinociceptive activity. In addition, compounds VII d, f, j, p showed statistically significant anti-inflammatory activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7542c364245eca5fd475f33ae6ab97ff https://pubmed.ncbi.nlm.nih.gov/9648280 Zobrazit plný text záznamu Full Text from ScienceDirect