Selective toxicity of ethacrynic acid towards lymphocytes of chronic lymphocytic leukemia in vitro

Autor:	P R, Twentyman, E, Lambert, M, Müller, J K, Rees
Rok vydání:	1992
Předmět:	Leukemia Myeloid Acute Ethacrynic Acid Dose-Response Relationship Drug Cell Survival Leukemia Myelogenous Chronic BCR-ABL Positive Tumor Cells Cultured Humans Lymphocytes In Vitro Techniques Leukemia Lymphocytic Chronic B-Cell
Zdroj:	Leukemia. 6(7)
ISSN:	0887-6924
Popis:	We have used the MTT colorimetric assay to determine the sensitivity to ethacrynic acid of lymphocytes from normal donors and of peripheral blood cells from leukaemia patients. Whereas normal lymphocytes and cells from acute or chronic myeloid leukaemia showed similar sensitivities (median inhibitory dose, ID50 = 20-22 microM), lymphocytes from chronic lymphocytic leukaemia patients were much more sensitive (ID50 = 6 microM). This result was found irrespective of the assay duration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7542115670246669e981d9d07a414727 https://pubmed.ncbi.nlm.nih.gov/1625494 Zobrazit plný text záznamu