Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP

Autor:	G W, Chacko, S, Tridandapani, J E, Damen, L, Liu, G, Krystal, K M, Coggeshall
Rok vydání:	1996
Předmět:	src Homology Domains B-Lymphocytes Mice Phosphatidylinositol-3 4 5-Trisphosphate 5-Phosphatases Inositol Polyphosphate 5-Phosphatases Animals Down-Regulation Tyrosine Phosphorylation Lymphocyte Activation Phosphoric Monoester Hydrolases Cell Line Signal Transduction
Zdroj:	Journal of immunology (Baltimore, Md. : 1950). 157(6)
ISSN:	0022-1767
Popis:	Stimulation of the B cell Ag receptor (BCR) has been reported to induce tyrosine phosphorylation of a 145-kDa protein and its association with the adapter protein Shc. We have identified this protein as the novel inositol polyphosphate 5-phosphatase (SHIP). Further analysis revealed that both maximal phosphorylation of SHIP and its association with Shc require co-clustering with the Fc receptor for IgG (Fc gamma RII) rather than stimulation of the BCR alone. Since co-clustering of the BCR and Fc gamma RII also down-regulates proliferation induced by Ag receptor stimulation, we hypothesize that tyrosine phosphorylation of SHIP and its association with Shc contribute to negative signaling through effects on inositol and phosphatidylinositol metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::753baf21a5e80442d4b492c2e9df4d9a https://pubmed.ncbi.nlm.nih.gov/8805618 Zobrazit plný text záznamu