Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3

Autor:	Malcolm P, Huestis, Darlene, Dela Cruz, Antonio G, DiPasquale, Matthew R, Durk, Charles, Eigenbrot, Paul, Gibbons, Alberto, Gobbi, Thomas L, Hunsaker, Hank, La, Dennis H, Leung, Wendy, Liu, Shiva, Malek, Mark, Merchant, John G, Moffat, Christine S, Muli, Christine J, Orr, Brendan T, Parr, Frances, Shanahan, Christopher J, Sneeringer, Weiru, Wang, Ivana, Yen, Jianping, Yin, Michael, Siu, Joachim, Rudolph
Rok vydání:	2021
Předmět:	Molecular Structure Phenylurea Compounds Mice Nude Drug Synergism Crystallography X-Ray Xenograft Model Antitumor Assays Madin Darby Canine Kidney Cells Drug Combinations Structure-Activity Relationship Dogs Piperidines Cell Line Tumor Neoplasms Mutation Animals Azetidines Humans Female raf Kinases Protein Kinase Inhibitors Cell Proliferation Protein Binding Quinazolinones
Zdroj:	Journal of medicinal chemistry. 64(7)
ISSN:	1520-4804
Popis:	Optimization of a series of aryl urea RAF inhibitors led to the identification of type II pan-RAF inhibitor GNE-0749 (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::752defb2c13d02753ec2386945c69621 https://pubmed.ncbi.nlm.nih.gov/33780623 Zobrazit plný text záznamu