| Autor: |
Jian-ping, Li, Xu, Zhang, Xiao-feng, Li, Zhe, Qu, Jing-bo, Gao, Xu-ying, Huang, Xian-zhi, Liu |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 24(5) |
| ISSN: |
1003-9406 |
| Popis: |
To identify a novel HLA allele in Chinese population.A new HLA-B allele was initially detected by an usual PCR-SSP and PCR-SSOP in routine typing HLA allele. Sequence-based typing (SBT) was used to identify and analysis the difference between the new allele and HLA-B 4409 allele.The HLA-B exon 3 nucleotide sequence of the novel allele was different from all other known alleles. The allele had 3 nucleotides replaced of the closest matching B 4409 allele at nt538(GC), nt539(AT) and nt540 (CG) in exon 3, resulting in an amino acid change from D(GAC) to L(CTG) at codon 180.A novel HLA allele was confirmed by the SBT and it was officially designated as HLA-B 4446 by WHO Nomenclature Committee for Factors of the HLA System in September,2005. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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