Study of erythromycin A decomposition products in aqueous solution by solid-phase microextraction/liquid chromatography/tandem mass spectrometry

Autor:	D A, Volmer, J P, Hui
Rok vydání:	1998
Předmět:	Solutions Drug Stability Indicators and Reagents Chromatography Thin Layer Hydrogen-Ion Concentration Mass Spectrometry Erythromycin
Zdroj:	Rapid communications in mass spectrometry : RCM. 12(3)
ISSN:	0951-4198
Popis:	The decomposition of erythromycin A (EA) in aqueous solution was examined in the pH range 2-13 by means of combined solid-phase microextraction (SPME) and liquid chromatography/electrospray ionization tandem mass spectrometry. Degradation of EA, especially at lower pH values (pHor = 3), was very rapid and yielded a wide variety of decomposition products. Identification of these degradation products was achieved by means of tandem mass spectrometry in the product ion and precursor ion scan modes. Anhydroerythromycin A was shown to be the major reaction product in both acidic and basic solutions. Among the different SPME fibers investigated for extraction from aqueous solutions, polydimethylsiloxane/divinylbenzene exhibited the best performance for EA and its degradation products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::74ead60456f86cb564d944b1c8b1e7d7 https://pubmed.ncbi.nlm.nih.gov/12112278 Zobrazit plný text záznamu Plný text