| Autor: |
Huishan, Guo, Maneka, Chitiprolu, Luc, Roncevic, Charlotte, Javalet, Fiona J, Hemming, My Tran, Trung, Lingrui, Meng, Elyse, Latreille, Christiano, Tanese de Souza, Danielle, McCulloch, R Mitchell, Baldwin, Rebecca, Auer, Jocelyn, Côté, Ryan Charles, Russell, Rémy, Sadoul, Derrick, Gibbings |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Developmental cell. 43(6) |
| ISSN: |
1878-1551 |
| Popis: |
Autophagy and autophagy-related genes (Atg) have been attributed prominent roles in tumorigenesis, tumor growth, and metastasis. Extracellular vesicles called exosomes are also implicated in cancer metastasis. Here, we demonstrate that exosome production is strongly reduced in cells lacking Atg5 and Atg16L1, but this is independent of Atg7 and canonical autophagy. Atg5 specifically decreases acidification of late endosomes where exosomes are produced, disrupting the acidifying V |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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