| Autor: |
Sherein G, Elgendy, Ehsan Mw, El-Sabaa, Shabaan H, Ahmed, Samir Sm, Eid, Mohamed A, El-Feky |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
The Egyptian journal of immunology. 28(1) |
| ISSN: |
1110-4902 |
| Popis: |
Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of the anti-tumor activity, however; the role of regulatory B cells (B-regs) in breast cancer (BC) remains unclear. This study intended to assess the frequency of peripheral B-regs phenotypes in patients with BC, and to determine the relation between these phenotypes and the patient's clinicopathological characters. The expressions of the immune cell populations were analyzed by four-color flow cytometry in 40 naïve BC patients and 10 age-matched apparently healthy individuals as controls attending the department of Clinical Oncology and Nuclear Medicine at Assiut University Hospitals. The percentages of B-regs phenotypes CD19+IL10+ and CD19+CD24hiCD27+IL10+ were higher in BC patients than in the controls. The percentage of CD19+IL10+ B cells phenotype was significantly associated with the HER-2 expression levels, T, and N stages of BC. In conclusion, high percentage of B-regs phenotypes CD19+IL10+ and CD19+CD24hiCD27+IL10+ in BC patients indicates a possible role in immune suppression during the development of BC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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