[Clinico-biological issues of systemic lupus erythematosus patients]
| Autor: | Iulia Codruţa, Belibou, Codrina, Ancuţa, Smaranda, Miu, E, Ancuţa, Carmen, Păstrăguş, Rodica, Chirieac |
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| Jazyk: | Romanian; Moldavian; Moldovan |
| Rok vydání: | 2012 |
| Předmět: |
Male
Romania Arthritis Exanthema Middle Aged Risk Assessment Severity of Illness Index Age Distribution Cardiovascular Diseases Risk Factors Antibodies Antinuclear Prevalence Quality of Life Humans Immunologic Factors Lupus Erythematosus Systemic Female Kidney Diseases Age of Onset Nervous System Diseases Sex Distribution Algorithms Biomarkers Retrospective Studies |
| Zdroj: | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 116(1) |
| ISSN: | 0048-7848 |
| Popis: | To investigate clinical and biological aspects and to evaluate potential relation with activity and damage indexes in patients with Systemic Lupus Erythematosus (SLE).Retrospective observational study in 30 consecutive SLE patients (ACR 1997 diagnostic criteria) assessed according to a standard protocol including demographic, clinical and biological (hematology, inflammatory, immunology) data, disease activity (SLEDAI) and damage (SLICC/ACR).90% SLE women with a mean age of 45.53+13.57 years and a mean age at onset of 31.10 +/- 9.20 years, presenting mainly with skin (43.33%) and small joint (56.66%) involvement, but also with renal (26.66%), cardio-vascular (26.66%) and neurological (6.66%); high anti-DNA double stranded antibodies (30% cases; mean 40.63 +/- 71.62IU/L) and low C3 levels (26.66%; mean 100.63 +/- 26.06 IU/L) have been reported, while more than 76% SLE patients displayed a low disease activity (mean SLEDAI 4 +/- 3.64) and limited damage (mean SLICC/ACR 1.4 +/- 0.85). Statistically significant correlation (p0.05) have been identified between SLEDAI and SLICC/ACR (r = 0.477), anti-DNA double stranded and SLEDAI (r = 0.515) respectively SLICC/ACR (r = 0.404), age at onset respectively current age and SLICC/ACR (r1 = 0.495, r2 = 0.468).The clinical and biological study based on data from consecutive SLE patients has offered a comprehensive approach of different disease subtypes in North-East Romania. The predominance of currently low disease activity and minimal damage disease profile could reflect either SLE particularities or the expected effects of early individualized therapy. |
| Databáze: | OpenAIRE |
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