HIV-1 infection and pregnancy in young women in Brazil: socioeconomic and drug resistance profiles in a cross-sectional study
| Autor: | Lima, Yanna Andressa Ramos, Reis, Mônica Nogueira Guarda, Cardoso, Ludimila Paula Vaz, Stefani, Mariane Martins Araújo |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adolescent
Anti-HIV Agents HIV Infections Vulnerable Populations Young Adult Pregnancy Risk Factors Drug Resistance Viral Humans Pregnancy Complications Infectious young women Research Infant Newborn virus diseases Viral Load Sex Work Infectious Disease Transmission Vertical CD4 Lymphocyte Count Cross-Sectional Studies pol Gene Products Human Immunodeficiency Virus Drug resistance HIV-1 HIV/AIDS Female Brazil |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | Objectives To describe socioeconomic and antiretroviral (ARV) drug resistance profiles among young pregnant women infected with HIV-1. Setting A public health antenatal programme responsible for screening ∼90 000 pregnant women per year for nine different infectious diseases in Central Western Brazil. Participants 96 young pregnant women (15–24 years) infected with HIV-1. Primary and secondary outcome measures Standard interviews and blood samples were taken at the time of recruitment, at the first medical appointment after confirmation of diagnosis of HIV-1 infection, and before ARV prophylaxis initiation. Clinical and laboratory data were retrieved from medical files. HIV-1 pol gene sequences (entire protease/PR, partial reverse transcriptase/RT) were obtained from plasma RNA. ARV resistance mutations (CPR/Stanford HIV-1; International AIDS Society-USA databases) were identified. Results The median age was 21 years; most reported |
| Databáze: | OpenAIRE |
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