The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra, and crystallographic data. CCDC 1431476. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc04399a Click here for additional data file. Click here for additional data file
| Autor: | Fox, J. C., Gilligan, R. E., Pitts, A. K., Bennett, H. R., Gaunt, M. J. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Chemical Science |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a copper-catalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structural complexity of the natural product framework. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|