What about the males? the
| Autor: | Jonathon D, Walsh, Olivier, Boivin, Maureen M, Barr |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Neurons Neurotransmitter Agents Sex Characteristics Neuronal Plasticity TRPP Cation Channels Animal Structures Cell Cycle Proteins Polycystic Kidney Autosomal Dominant Nervous System Article DNA-Binding Proteins Disease Models Animal Extracellular Vesicles Sexual Behavior Animal Nondisjunction Genetic Interneurons Animals Humans Hermaphroditic Organisms Cilia CRISPR-Cas Systems Caenorhabditis elegans Caenorhabditis elegans Proteins Transcription Factors |
| Zdroj: | J Neurogenet |
| ISSN: | 1563-5260 |
| Popis: | Sexual dimorphism is a device that supports genetic diversity while providing selective pressure against speciation. This phenomenon is at the core of sexually reproducing organisms. Caenorhabditis elegans provides a unique experimental system where males exist in a primarily hermaphroditic species. Early works of John Sulson, Robert Horvitz, and John White provided a complete map of the hermaphrodite nervous system, and recently the male nervous system was added. This addition completely realized the vision of C. elegans pioneer Sydney Brenner: a model organism with an entirely mapped nervous system. With this ‘connectome’ of information available, great strides have been made toward understanding concepts such as how a sex-shared nervous system (in hermaphrodites and males) can give rise to sex-specific functions, how neural plasticity plays a role in developing a dimorphic nervous system, and how a shared nervous system receives and processes external cues in a sexually-dimorphic manner to generate sex-specific behaviors. In C. elegans, the intricacies of male-mating behavior have been crucial for studying the function and circuitry of the male-specific nervous system and used as a model for studying human autosomal dominant polycystic kidney disease (ADPKD). With the emergence of CRISPR, a seemingly limitless tool for generating genomic mutations with pinpoint precision, the C. elegans model system will continue to be a useful instrument for pioneering research in the fields of behavior, reproductive biology, and neurogenetics. |
| Databáze: | OpenAIRE |
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