| Autor: |
Bo, Feng, He-Yun, Zhu, Jiao, Guan, Cheng-Yi, Hao, Jing-Can, Duan, Jing-Kai, Gu |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 36(5) |
| ISSN: |
1001-4454 |
| Popis: |
To compare the pharmacokinetics of gentiopicroside and Gentianae Radix extract in rats and assess the effect of other components in Gentianae Radix on the pharmacokinetics of gentiopicroside.The rats were oral administrated with gentiopicroside and Gentianae Radix extract, the content of geritiopicroside was chosen as index and determined by HPLC. The pharmacokinetic parameters were calculated with DAS 2.1.1 program.The concentration-time curve of gentiopicroside and Gentianae Radix extract was described by two compartment model. The main pharmacokinetic parameters of gentiopicroside and Gentianae Radix extract were: C(max) (16.53 +/- 0.37) g/mL and (16.61 +/- 0.49) g/mL, T(max) 0.25 h and 1.5 h, t1/2(alpha) (0.20 +/- 0.04) h and (0.69 +/- 0. 14) h, t /2 (beta) (0.64 +/- 0.08) hand (0.80 +/- 0.11) h, AUC(0-infinity) (18.20 +/- 1.97) g x h/mL and (39.20 +/- 1.18) g x h/mL, CL( 2.75 +/- 0.32) L/(h x kg) and (1.22 +/- 0.04) L (h x kg), respectively.There are significantly differences in pharmacokinetic parameters between gentiopicroside and Gentianae Radix extract in rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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