| Autor: |
L A, Uphouse, S P, Welch, C R, Ward, E F, Ellis, J P, Embrey |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
European journal of pharmacology. 242(1) |
| ISSN: |
0014-2999 |
| Popis: |
Systemic and intrathecally administered ketorolac produced antinociception in the p-phenylquinone test, but not in the tail-flick or hot-plate tests. Antagonists of the subtypes of opioid receptors were used to evaluate the interaction of ketorolac with these receptors. Intrathecally administered kappa-opioid receptor antagonist nor-binaltorphimine dihydrochloride blocked the antinociceptive effects of systemic ketorolac and intrathecally administered ketorolac. Naloxone and ICI 174,864 failed to block the effects of ketorolac. Activation of nor-binaltorphimine-sensitive receptors appears to be an integral element in the mechanism of antinociception of ketorolac at the spinal level. Ketorolac did not precipitate withdrawal jumping in morphine-tolerant mice demonstrating that ketorolac does not act as a mixed agonist-antagonist at the opioid receptor. We suggest that neuraxial placement of ketorolac may prove useful in the clinical setting for the management of acute pain in humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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