[The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate]

Autor: Siyi, Zhang, Don, Robertson
Rok vydání: 2003
Předmět:
Zdroj: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology. 17(9)
Popis: To investigate the way how sodium salicylate affects cochlear function and discuss its possible mechanism.Sodium salicylate was perfused through guinea pig cochlea. The thresholds and input-output (I/O) functions of compound action potential (CAP) and summating potential (SP) were monitored during the perfusion.Sodium salicylate caused a significant change of CAP and SP threshold as well as I/O curve. The relationship between CAP and SP threshold change at 10 kHz during perfusion with 10 mmol/L salicylate tends to be 1:1.Outer hair cells are most likely to be the sites of action of sodium salicylate and this action on the outer hair cell active process might lead to its ototoxicity.
Databáze: OpenAIRE