Autor: |
Siyi, Zhang, Don, Robertson |
Rok vydání: |
2003 |
Předmět: |
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Zdroj: |
Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology. 17(9) |
Popis: |
To investigate the way how sodium salicylate affects cochlear function and discuss its possible mechanism.Sodium salicylate was perfused through guinea pig cochlea. The thresholds and input-output (I/O) functions of compound action potential (CAP) and summating potential (SP) were monitored during the perfusion.Sodium salicylate caused a significant change of CAP and SP threshold as well as I/O curve. The relationship between CAP and SP threshold change at 10 kHz during perfusion with 10 mmol/L salicylate tends to be 1:1.Outer hair cells are most likely to be the sites of action of sodium salicylate and this action on the outer hair cell active process might lead to its ototoxicity. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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