Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor

Autor:	A, Clairmont, D, Tessman, A, Stock, S, Nicolai, W, Stahl, H, Sies
Rok vydání:	1996
Předmět:	Cell Nucleus Calcitriol Connexin 43 Gap Junctions Humans Receptors Calcitriol Cell Communication RNA Messenger Fibroblasts Vitamin D Skin
Zdroj:	Carcinogenesis. 17(6)
ISSN:	0143-3334
Popis:	The physiologically active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Parallel to the increase in cell-cell communication, we observed a VDR-dependent increase in connexin43 protein and connexin43 mRNA levels. These results suggest that 1alpha,25-dihydroxyvitamin D3 affects gap junctional intercellular communication at the level of transcription or of mRNA stability via the nuclear VDR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::74283f7ecc1d3d749ca558a20115f5a8 https://pubmed.ncbi.nlm.nih.gov/8681462 Zobrazit plný text záznamu