Expression of cytokine genes in adhesions on uterine tubes

Autor:	A V, Zhdanov, M P, Davydova, T G, Gabuniya, L V, Van'ko, T A, Nazarenko, V I, Kulakov, G T, Sukhikh
Rok vydání:	2003
Předmět:	Tumor Necrosis Factor-alpha Interleukins Gene Expression Tissue Adhesions Fallopian Tube Diseases Feedback Interferon-gamma Gene Expression Regulation Transforming Growth Factor beta Cytokines Humans Female RNA Messenger Inflammation Mediators
Zdroj:	Bulletin of experimental biology and medicine. 134(5)
ISSN:	0007-4888
Popis:	We studied expression of genes of interleukins, interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta(2) in adhesions on uterine tubes. In tubal adhesions the intensity of production of mRNA for proinflammatory cytokines, antiinflammatory cytokine interleukin-10, and regulator of cell proliferation surpassed that in normal tissues by 2.5-7.4, 2.2, and 50.2 times, respectively. Correlations were found between production of mRNA for tumor necrosis factor-alpha and transforming growth factor-beta(2), interleukin-12, and interferon-gamma and interleukin-12 and transforming growth factor-beta(2). Our results suggest that expression of these genes during adhesion formation is regulated by the feedback mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::741a44557ff300696c9dd26d3e49a0ac https://pubmed.ncbi.nlm.nih.gov/12802454 Zobrazit plný text záznamu Full text from SpringerLink