In vitro and in vivo activity of eugenol on human herpesvirus

Autor:	F, Benencia, M C, Courrèges
Rok vydání:	2000
Předmět:	Mice Inbred BALB C Dose-Response Relationship Drug Herpesvirus 2 Human Acyclovir Herpes Simplex Herpesvirus 1 Human Microbial Sensitivity Tests Antiviral Agents Disease Models Animal Drug Combinations Mice Chlorocebus aethiops Eugenol Animals Humans Vero Cells
Zdroj:	Phytotherapy research : PTR. 14(7)
ISSN:	0951-418X
Popis:	Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25.6 microg/mL and 16.2 microg/mL for HSV-1 and HSV-2 respectively, 250 microg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol-acyclovir combinations synergistically inhibited herpesvirus replication in vitro. Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::73ebb130e560b426326f0b2a1f4e63b4 https://pubmed.ncbi.nlm.nih.gov/11054837 Zobrazit plný text záznamu Plný text