| Autor: |
Cui Lan, Bai, Takako, Osaki, Hideo, Yonezawa, Tomoko, Hanawa, Cynthia, Zaman, Satoshi, Kurata, Shigeru, Kamiya, Hideyuki, Tanaka |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Microbiology and immunology. 54(9) |
| ISSN: |
0385-5600 |
| Popis: |
Amu-ru 7, a Mongolian folk medicine, is used to treat digestive diseases such as gastritis and gastric and duodenal ulcers. We examined the effect of Amu-ru 7 on the growth and viability of Helicobacter pylori in vivo and in vitro. By the agar dilution method, the MIC of Amu-ru 7 for H. pylori strains was shown to be 100-200 μg/mL with a MIC(90) of 200 μg/mL. Two hundred micrograms per milliliter of Amu-ru 7 exhibited potent bactericidal activity against H. pylori in the stationary phase of growth 6 hr after treatment. Amu-ru 7 inhibited the growth of both AMPC-resistant and CAM-resistant strains, and also had a combined effect with AMPC on AMPC-resistant strain 403. The Amu-ru 7 inhibited biofilm formation by H. pylori and induced morphological changes, such as bleb-like formation and shortening of the cell. Although colonization of the stomach of the Mongolian gerbil by H. pylori was not cured by treatment with Amu-ru 7, both the mean number of H. pylori colonized and the colonization rate were decreased in Amu-ru 7 treated gerbils. These results suggest the effectiveness Amu-ru 7 as an adjunct therapy for eradication therapies consisting of a PPI combined with antibiotics. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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