Ticlopidine-induced aplastic anemia: development of chromosomal abnormalities and response to immunosuppressive therapy

Autor:	V A, Pullarkat, H, Rho, J L, Murata-Collins, H A, Liebman
Rok vydání:	2000
Předmět:	Aged 80 and over Chromosome Aberrations Male Ticlopidine Anemia Aplastic Chromosome Disorders Dexamethasone Treatment Outcome Fibrinolytic Agents Bone Marrow Cyclosporine Humans Immunosuppressive Agents Platelet Aggregation Inhibitors Aged
Zdroj:	American journal of hematology. 63(3)
ISSN:	0361-8609
Popis:	Severe aplastic anemia is a well-recognized complication of ticlopidine therapy that carries a high mortality. Therapy with colony-stimulating factors or corticosteroids has been largely ineffective in this disorder. We report a case of ticlopidine-induced aplastic anemia that was successfully treated with cyclosporine and high-dose dexamethasone. The patient rapidly responded to immunosuppressive therapy and had a normal hemogram after cessation of immunosuppression. On long-term follow-up, the patient developed a progressive macrocytic anemia. Repeat bone marrow evaluation demonstrated myelodysplasia with erythroid hypoplasia. An associated chromosomal abnormality consisting of a t(3;16) (q21; p13.3) translocation was detected. This is the first report of a chromosomal abnormality associated with ticlopidine induced marrow aplastic anemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7398a49aea3337acba84d1200558e4b5 https://pubmed.ncbi.nlm.nih.gov/10679804 Zobrazit plný text záznamu Plný text