| Autor: |
Tomasz, Basta, Robert, Jach, Joanna, Streb, Wioletta, Hosiawa, Iwona, Gawron |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Przeglad lekarski. 71(12) |
| ISSN: |
0033-2240 |
| Popis: |
Cervical intraepithelial neoplasia--CIN affects women in their repro- ductive life period. CIN may proceed squamous cervical cancer. CIN is divided into: CIN1, CIN2, CIN3. CIN3 comprises cervical cancer in situ- CIS which is the true precancer state within the cervix. CIN, depending on grade may progress, regress or persist for many years. According to a few publication vitamins C, E and A may protect against carcinogenesis within the cervix. The aim of this paper was evalua- tion of vitamins A and E serum concentration of cervical intraepithelial neoplasia patients. The study material consisted of 289 women aged 25-60 years diagnosed with CIN and early invasive cervical cancer IA. The subjects of the study were selected amongst participants of National Cervical Cancer Screen- ing Program attending Department of Gynecology and Oncology of Jagiellonian University Medical College in Krakow. The control group consisted of 44 women aged 28-56 years diagnosed and treated in the same centre and period due to a non oncologic gynecologic conditions. Serum vitamin A and E was measured with HPLC method with ultraviolet detector (UV) (254 nm).Medium serum vitamin A concentration in the study group was 2.67 ± 1.15 mg/l and was significantly (p0.001) lower than in control group -3.81 ± 1.62 mg/l. Mean serum vitamin E concentration in the study group was 3.95 ± 1.93 mg/l and was also significantly (p0.001) lower than in control group (8.63 ± 2.84 mg/l). To conclude, the observed significantly lower vitamins A and E serum concentrations may be related to the cervical neoplasia process. The normal vitamin A and E serum levels may have a protective effect against cervical carcinogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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