Common and Rare Genetic Variants Associated With Alzheimer's Disease

Autor:	Hany E, Marei, Asmaa, Althani, Jaana, Suhonen, Mohamed E, El Zowalaty, Mohammad A, Albanna, Carlo, Cenciarelli, Tengfei, Wang, Thomas, Caceci
Rok vydání:	2015
Předmět:	Alzheimer Disease Brain Humans Genetic Predisposition to Disease Polymorphism Single Nucleotide Genome-Wide Association Study Signal Transduction
Zdroj:	Journal of cellular physiology. 231(7)
ISSN:	1097-4652
Popis:	Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis of the disease before damaging of the brain, and the failure to explore its complex underlying molecular mechanisms. Recent technological advances in genome-wide association studies (GWAS) and high throughput next generation whole genome, and exome sequencing had deciphered many of AD-related loci, and discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD molecular pathways. Highlighting altered molecular pathways linked to AD pathogenesis is crucial to identify novel diagnostic and therapeutic AD targets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::736d849a352cc4300982472bd75e2e33 https://pubmed.ncbi.nlm.nih.gov/26496533 Zobrazit plný text záznamu Plný text