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Autor:	Omid, Sadatpour, Mohammad Taha, Ebrahimi, Maryam, Akhtari, Nooshin, Ahmadzadeh, Mahdi, Vojdanian, Ahmadreza, Jamshidi, Elham, Farhadi, Mahdi, Mahmoudi
Rok vydání:	2022
Předmět:	Matrix Metalloproteinase 8 Matrix Metalloproteinase 9 Macrophage Colony-Stimulating Factor Macrophages Bone Morphogenetic Proteins Purinergic P1 Receptor Agonists Receptors Purinergic P1 Humans Spondylitis Ankylosing Inflammation Mediators Severity of Illness Index
Zdroj:	BMC musculoskeletal disorders. 23(1)
ISSN:	1471-2474
Popis:	Ankylosing spondylitis (AS) is an inflammatory autoimmune disease that mostly affects different joints of the body. Macrophages are the predominant cells that mediate disease progression by secreting several pro-inflammatory mediators. Different receptors are involved in macrophages' function including the adenosine receptors (AR). Our main objective in this study was to assess the effect of applying AMonocytes were isolated from the whole blood of 28 individuals (AS patients and healthy controls in a 1:1 ratio). Macrophages were differentiated using macrophage colony-stimulating factor (M-CSF), and flow cytometry was performed to confirm surface markers. CGS-21,680 was used to treat cells that had been differentiated. Using SYBR green real-time PCR, relative gene expression was determined.Activating ADue to the disability of A
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::73504000c51c8ac5c8efb3c674431711 https://pubmed.ncbi.nlm.nih.gov/36221125 Zobrazit plný text záznamu Full text from SpringerLink