| Autor: |
Xiao-hui, Zhou, Yun-hua, Yue, Hai-jun, Miao, Yu, Hong, Nuer, Ka-Bi |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 25(4) |
| ISSN: |
1003-9406 |
| Popis: |
To investigate the relationship between the low density lipoprotein receptor-related protein gene (LRP) 766C/T polymorphisms and Alzheimer's disease (AD) in Xinjiang Uygurs and Hans populations.Those included in the study wereor = 50 years of age and of either Xinjiang Uygur or Han descents. Two hundred and nine individuals had AD and 220 were healthy controls. They were recruited according to ADRDA-NINCDS criteriaîThe polymorphisms of the LRP gene were determined by the PCR-restriction fragment length polymorphism technique. The case-control analysis was adopted to analyze the frequencies of genotypes and alleles.(1) The distribution of genotypes or alleles of LRP gene had significant differences between the AD group and the control group in both the Xinjiang Uygurs and Hans populations (P0.05). (2) The frequencies of genotypes and alleles were significantly different between the Han AD and Han control group (P0.05). (3) The frequencies of genotypes and alleles in thoseor = 65 years were significantly different from that in others (P0.05). There was a significant increase of AD in the C allele carriers (OR=1.98, P0.05). (4) The frequencies of the CC genotype and C allele in female AD patients were higher than that in female controls (P0.05), and the C allele carriers had significant increase of AD (OR=2.927, P0.05).The LRP 766C/T polymorphisms were significantly different between the Chinese Xinjiang Uygur and Han populations. The LRP 766C/T polymorphisms might be associated with AD in the Han population, in females and those ofor = 65 years old. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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